{"id":530960,"date":"2021-06-25T19:16:11","date_gmt":"2021-06-25T18:16:11","guid":{"rendered":"https:\/\/pharma-hemp.com\/kaj-je-endokannabinoidni-sistem\/"},"modified":"2025-08-13T09:09:10","modified_gmt":"2025-08-13T08:09:10","slug":"kaj-je-endokannabinoidni-sistem","status":"publish","type":"post","link":"https:\/\/pharma-hemp.com\/sl\/kaj-je-endokannabinoidni-sistem\/","title":{"rendered":"KAJ JE ENDOKANNABINOIDNI SISTEM?"},"content":{"rendered":"

Endokanabinoidni sistem (ECS) je ukazno-nadzorni niz biokemijskih komunikacij med endokanabinoidi, ki jih \u010dlove\u0161ko telo naravno proizvaja, in receptorji, ki sodelujejo v procesih, kot so razmi\u0161ljanje, spomin, koordinacija, u\u017eitek in zaznavanje \u010dasa.<\/p>\n

Odkritje<\/h3>\n

Leta 1988 je vladna \u0161tudija na Medicinski fakulteti Univerze St. Louis, ki sta jo opravila Allyn Howlett in William Devane<\/a>, ugotovila, da imajo mo\u017egani sesalcev receptorska mesta, ki se odzivajo na spojine v konoplji. Izkazalo se je, da so ti receptorji, imenovani kanabinoidni receptorji, najpogostej\u0161a vrsta nevrotransmiterskih receptorjev v mo\u017eganih. Leta 1990 je bilo objavljeno, da je skupina z Nacionalnega in\u0161tituta za du\u0161evno zdravje, ki jo je vodila Lisa Matsuda<\/a>, preslikala zaporedje DNA, ki kodira kanabinoidni receptor v mo\u017eganih. Matsuda je tudi uspela klonirati ta receptor. To je odprlo vrata in pripeljalo do razvoja t.i. \u00bbknockout mi\u0161i\u00ab, ki nimajo receptorja, povezanega z G-proteini.<\/p>\n

Odkritje teh receptorjev je privedlo do odkritja naravnih nevrotransmiterjev, imenovanih endokanabinoidi. Prepoznanih je bilo ve\u010d kot pe\u0161\u010dica endokanabinoidov, skupaj s \u0161e pe\u0161\u010dico receptorjev, povezanih z G-proteini, ki sodelujejo s temi endokanabinoidi.<\/p>\n

Pri iskanju metaboli\u010dnih poti fitokanabinoidov in endokanabinoidov so znanstveniki v telesu naleteli na neznan molekularni signalni sistem, ki sodeluje pri uravnavanju \u0161irokega spektra biolo\u0161kih funkcij. Ta sistem so poimenovali ECS<\/strong>. Ko je v na\u0161em notranjem okolju zaznano neravnovesje, telo sintetizira endokanabinoide, ki sodelujejo s kanabinoidnimi receptorji. Razlogi za pojav tega stanja so lahko, da na\u0161e telo ne sintetizira dovolj endokanabinoidov, ali da telo ne proizvaja dovolj kanabinoidnih receptorjev, ali obilice encimov, ki razgrajujejo kanabinoide<\/a>, ali pa od zunanjih virov, kot so hrana in zdravila, ki zmanj\u0161ujejo signalizacijo ECS.<\/p>\n

Vloga ECS<\/h3>\n

Endokanabinoidni receptorji so koncentrirani v mo\u017eganih, vendar so prisotni tudi v \u017eiv\u010dnih tkivih po vsem telesu. Ko stanje, kot je po\u0161kodba, zvi\u0161ana telesna temperatura ali oku\u017eba, poru\u0161i telesno homeostazo, ECS pomaga le-to obnoviti.<\/p>\n

ECS igra pomembno vlogo pri normalnem delovanju telesnih sistemov, ki vklju\u010dujejo:<\/h4>\n
    \n
  • Centralni \u017eiv\u010dni sistem<\/li>\n
  • Kardiovaskularni sistem<\/li>\n
  • Prebavni sistem<\/li>\n
  • Reproduktivni sistem<\/li>\n
  • Skeletni sistem<\/li>\n
  • Imunski sistem<\/li>\n
  • Presnovne procese<\/li>\n<\/ul>\n

    ECS je pomemben posrednik pri urejanju:<\/h4>\n
      \n
    • Spomina in u\u010denja<\/li>\n
    • Apetita<\/li>\n
    • Odziva na stres<\/li>\n
    • Ob\u010dutka bole\u010dine<\/li>\n
    • Razpolo\u017eenja<\/li>\n
    • Spanja<\/li>\n
    • Vnetja<\/li>\n
    • Zasvojenosti z mamili<\/li>\n<\/ul>\n

      Kako CBD sodeluje z ECS?<\/h3>\n

      In smo le pri\u0161li do u\u010dinkov CBD-ja. Kot bomo videli, je njegov vpliv na endokanabinoidni sistem zapleten. Prvo presene\u010denje je lahko dejstvo, da ima CBD precej nizko afiniteto do endokanabinoidnih receptorjev. To pomeni, da CBD za receptorje ni prva izbira, vsekakor imajo raje bodisi prirojeni anandamid bodisi psihoaktivni THC.<\/p>\n

      Izkazalo se je, da je CBD tudi mo\u010dan negativni alosteri\u010dni modulator receptorja CB1. Te u\u010dinke lahko najbolj opazimo v prisotnosti THC-ja. Med \u0161tevilnimi drugimi funkcijami je odgovoren za nastanek vnetja. V primeru CB2 imamo spet opravka z nasprotnim u\u010dinkom THC-ja in CBD-ja. Medtem ko je prvi odgovoren za stimulacijo receptorjev, je CBD inverzni agonist receptorja CB2, zato oslabi njegovo u\u010dinkovitost. Prav temu mehanizmu lahko pripi\u0161emo protivnetne lastnosti CBD-ja, vendar je treba omeniti, da je bilo dokazano, da je kanabidiol pravzaprav precej \u0161ibek inverzni agonist CB2, zato je njegov vpliv na receptor zanemarljiv.<\/p>\n

      CBD vpliva tudi na ECS na dva pomembna na\u010dina: s spreminjanjem aktivnosti encimov in transportnih beljakovin tega sistema in s tem na koncentracijo anandamida, privzetega endokanabinoida. Ko gre za telesne sisteme, pogosto pozabimo, da sistem ni sestavljen samo iz receptorjev in namenskih nevrotransmiterjev, ampak tudi iz encimov, ki uravnavajo celoten mehanizem. V primeru ECS je eden klju\u010dnih encimov amid-hidrolaze ma\u0161\u010dobnih kislin. Kot vidimo, CBD tukaj ne deluje neposredno. Namesto tega pove\u010duje u\u010dinke naravnega elementa omenjenega sistema.<\/p>\n

      Drugi del sistema, ki prikazuje, kako \u0161iroki so u\u010dinki kanabidiola, so beljakovine, ki ve\u017eejo ma\u0161\u010dobne kisline. Zaradi tega se presnavlja manj anandamida; zato ostane dalje v sistemu in posledi\u010dno se pove\u010da njegov u\u010dinek.<\/p>\n

      Zaklju\u010dek<\/h3>\n

      Vloga ECS v homeostatski funkciji na\u0161ega telesa je neizpodbitna, njegovo vplivno podro\u010dje pa neverjetno. Poleg tega ima pomembno vlogo tudi pri apoptoti\u010dnih boleznih, delovanju mitohondrijev in mo\u017eganih. ECS morda ne bo le zagotovil odgovorov za bolezni, za katere ni znanega zdravila, ampak bi lahko tudi spremenil pristop k medicini.<\/p>\n","protected":false},"excerpt":{"rendered":"

      Endokanabinoidni sistem (ECS) je ukazno-nadzorni niz biokemijskih komunikacij med endokanabinoidi, ki jih \u010dlove\u0161ko telo naravno proizvaja, in receptorji, ki sodelujejo v procesih, kot so razmi\u0161ljanje, spomin, koordinacija, u\u017eitek in zaznavanje \u010dasa. Odkritje Leta 1988 je vladna \u0161tudija na Medicinski fakulteti Univerze St. Louis, ki sta jo opravila Allyn Howlett in William Devane, ugotovila, da imajo […]\n","protected":false},"author":23672,"featured_media":546070,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-530960","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nekategorizirano"],"acf":[],"yoast_head":"\nKAJ JE ENDOKANNABINOIDNI SISTEM? - Pharma Hemp<\/title>\n<meta name=\"description\" content=\"Endokanabinoidni receptorji so skoncentrirani v mo\u017eganih, vendar so prisotni tudi v \u017eiv\u010dnih tkivih po vsem telesu. 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